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Because coronary artery disease is common and may be unrecognized, it may be prudent not to discontinue metoprolol therapy abruptly even in patients treated only for hypertension.

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, at 24-hours post-dosing were 14 9, 16 10, 24 14, 27 22 and 27 20 reduction in exercise heart rate for doses of 50, 100, 200, 300 and 400 mg toprol-xl once a day, respectively.

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Early treatment during the early phase of definite or suspected acute myocardial infarction, treatment with metoprolol tartrate can be initiated as soon as possible after the patient s arrival.

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heart failure in the merit-hf study comparing metoprolol succinate extended-release in daily doses up to 200 mg mean dose 159 mg once-daily; n 1990 to placebo n 2001 , 10.

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